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Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitorcells in rats with cerebral ischemia

Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 472-485 doi: 10.1007/s11684-021-0832-y

Abstract: Hypoxia conditioning could increase the survival of transplanted neuronal progenitor cells (NPCs) inrats with cerebral ischemia but could also hinder neuronal differentiation partly by suppressing mitochondrialResveratrol was first applied during the neuronal differentiation of hcNPCs and concurrently promotedResveratrol promoted neuronal differentiation and increased the long-term survival of transplanted hcNPCsIn conclusion, resveratrol promoted the neuronal differentiation and therapeutic efficiency of hcNPCs

Keywords： neuronal progenitor cells     resveratrol     cerebral ischemia     neuronal differentiation     mitochondrial metabolism    

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EFFECTS OF TRANSPORT STRESS ON THE INTESTINES INVOLVING NEURONAL NITRIC OXIDE SYNTHASE

Frontiers of Agricultural Science and Engineering   Pages 285-295 doi: 10.15302/J-FASE-2022469

Abstract:

● Transport stress declined the level of leukocytes including lymphocytes in rat serum.

Keywords： intestine     nNOS     nNOS-positive neurons     transport stress    

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Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 70-74 doi: 10.1007/s11684-008-0013-2

Abstract: To investigate the relationship between protein aggregation and delayed neuronal death, we adopted ratThe results showed delayed neuronal death took place at 72 h after ischemia-reperfusion, protein aggregatesWe conclude that protein aggregation is one of the important factors leading to delayed neuronal death
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Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 63-69 doi: 10.1007/s11684-008-0012-3

Abstract: Neural progenitor cells (NPC) are those that are the source of neural cells for cell transplantationThe shortage in quantity and the limited life spans of primary cultured cells limit its widespread useHere we report that an immortalized neural progenitor cell strain, which we named as INPC, was successfullyThe INPC retained the biological characteristics of its original cells and provided a safe and reliableThe immortalized cells may show good long-term survival and do not elicit an acute immunological response

Keywords： immortalized     long-term survival     differentiation     capacity     genotype    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalcells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveWith the rapid advances in genome-editing and cloning using homologously recombined somatic cells, theneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem cells

Keywords： bovine     embryonic     induced     pluripotent stem cells    

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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: cell growth characteristics, ciliated cell differentiation, and function of human nasal epithelial cellsdensity appeared at 7th–10th culture day and declined with time, with the lifespan of ciliated cellsOverall, 10% of the cells in explant cultures and 20% of the cells in the dissociated tissue culturestissue culture techniques are suitable for growing well-differentiated nasal ciliated and non-ciliated cells, which have growth characteristics and ciliary activity similar to those of nasal epithelial cells 

Keywords： ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

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Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous propertiespotential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cellsculture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cellsMoreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown inMorphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

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Microbial electrolysis cells with biocathodes and driven by microbial fuel cells for simultaneous enhanced

Jingya SHEN,Yuliang SUN,Liping HUANG,Jinhui YANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1084-1095 doi: 10.1007/s11783-015-0805-y

Abstract: Previous tests have primarily examined Cu(II) and Co(II) removal in microbial electrolysis cells (MECs

Keywords： biocathode     microbial electrolysis cell     microbial fuel cell     Cu(II) removal     Co(II) removal    

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Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 1-2 doi: 10.15302/J-FASE-2019251

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Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible.

Keywords： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Title Author Date Type Operation

Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitorcells in rats with cerebral ischemia

Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang

Journal Article

EFFECTS OF TRANSPORT STRESS ON THE INTESTINES INVOLVING NEURONAL NITRIC OXIDE SYNTHASE

Journal Article

Protein aggregation in association with delayed neuronal death in rat model of brain ischemia

GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei

Journal Article

Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

Microbial electrolysis cells with biocathodes and driven by microbial fuel cells for simultaneous enhanced

Jingya SHEN,Yuliang SUN,Liping HUANG,Jinhui YANG

Journal Article

Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Journal Article

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article